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This question was answered on Sun 06, Dec 2009 09:35pm by Dr Bhupinder K, MD
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single Lymph node above pancreas noted on ultrasound imaging, should I be worried about pancreatic cancer?






    
Asked by sononicole (Female; 23; Appy (1998) Ear tubes (1989); Relevant drugs:Penicillin VK 500 mg Multi Vitamin ) on Sun 06, Dec 2009 06:46pm :

Hello, I have a question for the Doctor. First I will give you a little clinical history. I'm a 23 year old female, no major health problems, non smoker, never drink alcohol and I'm 5"7 177 lbs. I have no known family history of cancer or pancreatic cancer. I'm a contingent sonographer at a local hospital specializing in general and vascular ultrasound. I was letting the students scan me and they noticed a lymph node above my pancreas. The lymph node is well rounded, homogenous, and hypoechoic compared to the pancreatic tissue. There is no flow within this area, which is located above the pancreatic head/neck. The pancreas itself does not look enlarged and is homogenous and hyperechoic compared to the liver. I do not see any masses or any areas of concearn. The lymph node area measures 1.4 (long) 8.9 mm (AP) 1.5 (trans) My spleen is also on the prominent side measuring 12.2 cm's. I'm worried because I read in a few journals this could be a sign of pancreatic cancer if a lymph node is found near the pancreas, but most places say abnormality is over 1-2 cm. I have no medical insurance at the moment because I do contingent between 2 hospitals but I want to know if I should be concearned about this area and what I should do. Given the profession, and all the pathology I've seen this worries me to death. I also must tell you about a week ago I just got over a really bad sinus infection it must have been viral because I had severe Laryngitis and also on 12/2/2009 I had a root canal for a really bad infection in the pulp of my molar, I'm now on penicillin and finishing up my doses could this be why the lymph node is enlarged or looks prominent? or should I be worried about pancreatic cancer?

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Answer by Dr Bhupinder K, MD (doctor) on Sun 06, Dec 2009 09:35pm:

Hello, Welcome to the AMD forum of doctors and we are glad to lend you a helping hand. I can understand your confusion regarding the solitary swollen lymph node and the enlarged spleen. See, both these were incidental findings in your case which were seen only by coincidence on an ultrasound. Moreover, since you have a history of infection of the larynx and molar tooth, so the most rational cause of these findings is an infection. As you must be aware that the prime function of the lymph nodes and spleen is clearance of microorganisms and infections, so they usually swell up whenever there is association with various infections or inflammatory processes because of an increase in the defense activities of the organs. Normally the spleen is 11cm in craniocaudal length so 12.2 cm can be considered mild splenomegaly. It is true that anyone will have apprehension of a malignancy with such findings, but your history(age, non smoker, non alcoholic, no family history, no exposure to carcinogens) is defying it. In the absence of any symptoms of pancreatic malignancy like abdominal pain, weight loss, loss of appetite, diarrhea and jaundice; pancreatic malignancy is less likely. You are also right in saying that the size of the nodes greater than 2 cm is of concern and in your case, that is also not justifying. I would suggest you to repeat the scan after 12-15 days (lymph nodes take longer to return to normal size than the time they take to swell up) and if there is persistent node enlargement or splenomegaly, then you should consult a gastroenterologist/ hepatologist and get a CT abdomen and maybe a biopsy of the lymph node(percutaneous or endoscopic) done to confirm the diagnosis. Another possibility to be ruled out in that case would be a lymphoepithelial cyst of the pancreas. In this, there is a pancreatic cystic lesion lined by squamous epithelium with surrounding lymphoid stroma and filled with keratinous debris. I hope it helps. Take care and please do keep me posted in case you have any additional doubts. Kind regards.
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Follow up:

Clarification by sononicole on Sun 06, Dec 2009 11:37pm:
Thank you Doctor! I must also let you know my spleen has been the same size 12.2 for a year now and it was found incidently in my ultrasound class. A few of the sonographers at the hospital asked me if I ever had mono to which my reply was yes when I was 13, can the spleen stay enlarged after having that? I never had any problems or symptoms and did not think it was much of a big deal since most radiologist said they did not consider it spleenomegaly until it was past 13 cm on ultrasound. I however did have a CBC done a year ago which showed a normal hematocrit the only things that were slightly off were my WBC count was slightly high which was 13.4, normal WBC range is 3.5-10.5, my platelet count was low as well it was 113 normal range 150-450. I asked my aunt a year ago whom is an ER physician and she told me not to worry about the platelets unless they get below 90 and that the WBC really isnt that high to be of concearn and that the body changes. Do you agree with this? I have not had a CBC since so I don't know my levels as of today. The only thing I often feel is tired and fatigued all the time but this is an ongoing problem I have had for a few years now. I don't have any pain in my abdomen, no weightloss, no loss of appetite, no diarrhea usually and I haven't noticed my skin or whites of my eyes turning jaundice. I do however feel very nauseated but its been happening ever since the dentist started me on the Penicillin so I know thats what is making my stomach upset. What are the chances of someone with my history and age even having pancreatic cancer? I know I'm worrying myself but I just want to put my mind at ease.
Request for Clarification by Dr Bhupinder K, MD on Mon 07, Dec 2009 06:13am:
Hi, Many thanks for reposing your faith in the forum. In my opinion, the lymph node doesn’t appear to be a sinister one taking into account your young age, elevated WBC counts in recent past, history of sinusitis. However, not to take a chance, I’ll suggest a CT scan of abdomen after a course of antibiotics in case the WBC counts are still enlarged and the lymph node continues to persist as it will put to rest any speculation of an underlying sinister pathology like a cancer which doesn’t seem likely. As mentioned by Dr Anurag, if any other lymph node is palpable like in the neck or the axilla, then an FNAC from the mentioned regions should help. I sincerely hope that helps. Take care.


Comments:

Response by Dr. A. Srivastava on Mon 07, Dec 2009 01:33am:
Hi, Dr Bhupinder has nicely explained all possibilities of your unexpected incidental finding of lymph node. I would like to add a few points to it. As you said lymph node was an incidental findings by your students and presently there are no symptoms related to abdomen or jaundice etc( as mentioned by Dr Bhupinder) and there is no primary pathologic foci visible in the scan of pancreas, liver or any other abdominal organ( except spleen). Therefore I would advice you to keep your mind at rest for a while. You have history of ear tubes (so I feel may be you had frequent middle ear infections which can be inducible by frequent cold and flu too. Presently, you have sinus infection which can be allergic or viral infection with excessive mucus collection leading to stagnation of secretion and superimposed bacterial infection. So, lymph nodes may have enlarged due to viral infections or subclinical infections. Second possibility is that it can be part of generalized lymphadenopathy therefore an examination of all major lymph nodal groups like neck, axillary and inguinal area should be conducted and if there is any other palpable node found then some general causes of lymphadenopathies like TB, frequent and intermittent respiratory infections, kidney conditions should be ruled out. Mild splenomegaly is another finding you got but for that too we have good news for you!! Size of spleen varies according to racial differences and also antigenic stimulation due to infections can cause splenomegaly ranging from mild to moderate size. Associated generalized lymphadenopathy (if found upon examination) is frequent in many of these infectious causes. As your spleen size is still the same in one year then may be it is your actual size. Therefore as far as you don’t have any symptoms of pancreas problem, stay calm and eat healthy to improve your immune system. I would advice a complete blood count (WBC count may be increased due to your recurrent and present infection and mild lowering of platelet count also can occur in viral infections), hemoglobin (to check anemia), chest x-ray (or scan) should be conducted to reach to a diagnosis. There is a well known saying in medicines “General problems are generally found but rare conditions are rare”. Your young age also defies possibility of malignancy though I agree your profession is towards the higher side of risk. In such case I would advice you to keep all precautions as per recommendations of radiology to avoid unnecessary exposure to radiations. These are just precautionary steps so don’t panic stay stable minded and go ahead with your profession with safety. Lastly, I too agree for a follow-up scan but after your symptoms of sinus infection has subsided or at least after a month as lymph node enlargement takes a longer time to resolve after the infection is completely eradicated and later 6monthly. Hope this information helps you. Take care and do keep us posted in case of further doubts.

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