Hi
Welcome to the AMD forum!
I am sorry to say but you have the typical polycystic ovarian syndrome associated with polycystic disease of
the ovary, weight gain, insulin resistance and amenorrhea (no periods).
The excess sugar in the blood due to insulin resistance is sent to liver which faces a sugar overload. Hence
the liver enzymes become raised. The excess insulin stimulates the ovaries to produce large amounts of the
male hormone testosterone, hence its level increases.
If Dianette is not acting to reduce the excess androgen, then you can go on progesterone only pills on fixed
days of the cycle to help reduce the androgen level. Puncturing the cysts usually helps but has not helped in
your case.
The clue to your treatment response is weight reduction. Your endocrinologists should target a multi endocrine
pathology and rule out hypothyroidism, adrenal gland problems and Cushing’s syndrome. Kidney function tests
should also be done and the possibility of associated diabetes mellitus complicating the picture should be
ruled out.
If any other endocrine pathology is found to be associated, then it would explain why your weight is not going
down and you are not responding to the treatment of PCOS.
If by venous sampling all these have been ruled out then an exercise and diet plan should be chalked out and
some weight reduction tried. Once some weight comes down you will in all probability start responding to
treatment.
It is difficult to comment beyond this. Please discuss this with your endocrinologist. In all probability you
also have associated diabetes, so metformin alone is not sufficient to bring down the glucose level. Another
drug may need to be added. Hope you will benefit from this post and something may strike your doctors that
will help you get on to the road of recovery. Please feel free to ask if you have any other queries. Take
care!
