This question was answered on Fri 15, Feb 2008 07:00pm by Dr Bobby V, MD

Serum Immunofixation test result - What does IgG Kappa monoclonal protein detected in serum immunofixation test mean?

    
Asked by Unregistered on Fri 15, Feb 2008 09:23am

What does IgG Kappa monoclonal protein detected in serum immunofixation test mean? This is a follow up test for the protein electrophoresis test which detected a presence of monoclonal protein band.

Actions: | Forward |
Answer


Name 

Email 

Security code
Enter the text as shown above


E-Mail me when someone replies to this post
Answer by Dr Bobby V, MD  on Fri 15, Feb 2008 07:00pm:

Hi, The patient in question is being worked up for suspected multiple myeloma. Patients with multiple myeloma secrete abnormal levels of certain proteins called M protein. The investigation of M protein involve the following steps. First, the M protein is detected using protein electrophoresis. Second, the nature of the M protein is identified using Immunoelectrophoresis or Immunofixation. Lastly, the amount of M protein may be quantified using a test known as Single Radial Immunodiffusion or other techniques. To give a brief background, Protein Electrophoresis is used to seperate out the different protein classes present in blood serum using a small electric current. The seperated protein classes form different bands, and these are labelled as Albumin, Alpha 1, Alpha 2, Beta, and Gamma. The doctors are specifically interested in the Gamma band, and check if this Gamma band on electrophoresis is broad or narrow. Normal patients have a diffuse, broad Gamma band. In patients with multiple myeloma, PEP reveals a single, sharp protein band in the Gamma region. The initial protein electrophoresis (PEP) of the patient revealed a monoclonal protein band. This strengthened the clinical suspicion of Multiple Myeloma, and the next test, or serum Immunofixation test was ordered. A brief background of the Immunofixation test: We know that patients of multiple myeloma secrete immunoglobulins. These contain sub-parts called heavy-chains and light-chains. The heavy chains are usually of a type called IgG, may sometimes be IgA, and rarely be IgM, IgD, or IgE. The light chains in multiple myeloma patients are either Kappa or Lambda but not both. Normal patients have both Kappa and Lambda. The Immunofixation test thus identifies the type of light chain that a particular patient has; in this case the test was Kappa positive. The patient in question should now undergo other routine blood investigations, liver function tests, renal function tests, bone marrow aspirate and biopsy examination, radiological skeletal survey, and serum beta microglobulin test. Treatment should begin after confirming diagnosis and appropriate staging procedures.

If you find the site useful, please consider making a donation.  Click the button to donate.   

Please rate my answer (select the stars, no need to log in.)  

Comments:

Comment by Jay Keating on Tue 30, Nov 2010 07:05am:
My Immunofixation test revealed an IgG Kappa Monoclonal protein migrating in gamma region. The reference Range showed no Monoclonal Protein Detected. What does this mean?

This question is open for comments.  Please share your opinion.

Comments


Name 

Email 

Security code
Enter the text as shown above


E-Mail me when someone replies to this post


 
What users are searching right now on Ask Medical Doctor:
bacterial vaginosis and sex     iamfearaboutrabies     have trouble breathing at night     blood dyscarsia     Albumin levels     wartcure     littlewhiteblisters     Lowerabdominal     What do I take to get my voice back     excessive     whatcausesvaginitis     serotonin syndrome     curlz     neausea bloated and burning in lower stomach what is this i would like tio know     iwanttosex     medicines for erectile dysfunction     DTS     Ihavebeenfeel     Chronic afib     whatishpolyri     discomfort     purple soles of feet     spermonleg     howdoIloosefatonmyvagina     throbbingtinglingheadache     praziquental     db     Breastpain     semenax     dry dark flakey bumps on thighs     Hodgkin     Lower     Day     old pitted scars     preventative hiv drugs     policks     shoulder pain     Backup     when a man cums inside the woman where does it go     eggyolk     Hiatus hernia     pain increase after knee aspiration     Search for answersperipheral vascular disease     myalgia     nightpainonbicepsntricepsmuscles     alphabeticlistofdiseases     aboshan20tablet     WhatisPylotest     Should a 12 year old girl be masturbating     fever 13 days ear infection     Hemroid     body weight     Canyougetanstdfromeroticmessage     inflamation in the pennis     Search for answers     cerosisofliver     Search for answers     9IUmL     Blood in phlem     likoria mai pregnancy hoti hai     handjob     abcess in the gum     stomach     iamcurrentlystudyingbiology     isotretinoin     cozole uses     fatique     buttock abscess     praziquental     throbbingtinglingheadache     howdoIloosefatonmyvagina     spermonleg     purple soles of feet     discomfort     whatishpolyri     Chronic afib     Ihavebeenfeel     DTS     medicines for erectile dysfunction     iwanttosex     neausea bloated and burning in lower stomach what is this i would like tio know     curlz     serotonin syndrome     whatcausesvaginitis     excessive     cervical cancer     insomnia confusion     subserouscomponent     alphabeticlistofdiseases     nightpainonbicepsntricepsmuscles     myalgia     Search for answersperipheral vascular disease     pain increase after knee aspiration     Hiatus hernia     eggyolk     when a man cums inside the woman where does it go     Backup     shoulder pain     policks     preventative hiv drugs     old pitted scars     neausea bloated and burning in lower stomach what is this i would like tio know     Day     Lower     Hodgkin     dry dark flakey bumps on thighs     kids     howwould60ngml in blood work affect you     discoloration that looks black and blue in the inner corner of the eyes near the nose     epigastric pain mild     i have a pain in my knee that moves to my shin     9montholdbabywithvitiligo16845cura     wpadmin     sternum pain clear chest xray     women blood clots in urine     fatty liver     skin damage     inde     what causes sudden cross eye and dizzy     missed oeriods     wisdom     Male     Possible Rabies infection from bat without direct contact with the animal     aspirinrisks     120eye20is20going20inside     chroic pelvic pain     eating     overycancer     I have fluid type swelling under top of penis and down urine pipe     whatdoesitmeanifthelifverisdiffuselyincreasedinexhotextureandsize20cm     unmerriedladkiyokolikoriyakyohotahai     

©2011 - Ask Medical Doctor  |  All Rights Reserved
The site is not a replacement for professional medical opinion, examination, diagnosis or treatment. Always seek the advice of your medical doctor or other qualified health professional before starting any new treatment or making any changes to existing treatment. Do not delay seeking or disregard medical advice based on information written by any author on this site. No health questions and information on AskMedicalDoctor is regulated or evaluated by the Food and Drug Administration and therefore the information should not be used to diagnose, treat, cure or prevent any disease without the supervision of a medical doctor. Posts made to these forums express the views and opinions of the author, and not the administrators, moderators, or editorial staff and hence AskMedicalDoctor and its principals will accept no liabilities or responsibilities for the statements made.

Home | Terms & Conditions | Contact Us | Frequently Asked Questions | Disclaimer | Privacy Policy | Advertise with us
Stats