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This question was answered on Tue 17, Nov 2009 07:55am by Dr. A. Srivastava
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Hello - I'm a 44-year-old woman, healthy and physically fit with no medical conditions. Of late been having menorrhagia (11 days period, very heavy with clots, waking at night to change, etc) and have an appt for gynecologist in 2 months time. In meant



    
Asked by Concern44 (Female; 44; None to speak of. Have 2 healthy children born vaginally, now teenagers. I smoke about 10 cigarettes a day and drink minimal socially. Very fit and do "bootcamp" 3 times a week. Eat very healthy, lots of veggies and low fat diet. Probably drink too much coffee. No allergies. No meds. Family history includes brother with type 1 insulin dependent diabetes mellitus. Strong family history of thyroid disease in my mother and many aunts and uncles that side.; Relevant drugs:None ) on Tue 17, Nov 2009 06:44am

Hello - I'm a 44-year-old woman, healthy and physically fit with no medical conditions. Of late been having menorrhagia (11 days period, very heavy with clots, waking at night to change, etc) and have an appt for gynecologist in 2 months time. In meantime my family doc gave me a prescription for 10 days Provera to stop the bleeding. I smoke and am over 35. I have understood before i'm at risk for stroke and am scared to start the Provera. He says its ok - but I want to know the risk of stroke. I work out regularly and have low fat diet. thanks

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Answer by Dr. A. Srivastava (doctor) on Tue 17, Nov 2009 07:55am:

Hi, A warm welcome to AMD forum. I appreciate your sensible concern towards provera use but I am sure that your doctor has a valid reason before prescribing Provera. Provera is medroxyprogesterone injection and usually a third line of treatment for menorrhagia after Intra-Uterine Devices (IUDs),NSAIDs or combined OCPs. Most common side effects of Provera are menstrual changes such as irregular bleeding or spotting, headache, weight gain, abdominal pain and hot flushes. However, provera is not to be used or contraindicated in deep vein thrombosis, pulmonary embolism, and severe disease of the arteries such as stroke or heart attack. But it doesn’t mean that these contraindications are side-effects of the provera. Therefore, provera can not be the sole reason of stroke risk although regular smoking could be. Though you are doing regular exercise and quite diet conscious, but it is essential to quit smoking to prevent yourself from getting any heart diseases. In addition, I would advise you to consult a gynecologist to evaluate the reasons of menorrhagia. Most common reason in your case could be pre-menopausal related that is quite natural. Other reasons could be infection, hormonal imbalance, endometriosis, fibroid and cervical changes. Investigations that can help to evaluate these conditions will be a pelvic and rectal examination, pap smear, pelvic ultrasound scan and endometrial biopsy. Treatment will depend upon treating the cause. Hope this information proves helpful to you. You look pretty healthy in your picture, therefore I would suggest lifestyle modification such as quitting smoking, regular exercise and take balanced diet to remain the same as your age progresses. Take care & regards.
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Comments:

Response by Dr.Kokil Mathur on Tue 17, Nov 2009 10:18am:
Hi I completely agree with Dr Srivastava’s approach to your post and his views. Yes, you must quit smoking if you are to continue Provera. In smokers taking Provera increases the risk of clots and thus deep vein thrombosis and stroke. As Dr Srivastava pointed out, the cause for menorrhagia has to be found out. If it is due to menopause or pre menopause, then Provera should not be taken as it masks the symptoms of menopause. Please discuss this with your doctor. Please let me know if there is any thing else and do keep me posted. Take care!

Comment by Unregistered on Sun 22, Nov 2009 08:35pm:
Thank you for the comments. I didn't take Provera afterall because of the comments and will wait for the gyne specialist appointment - which was my gut feeling - thanks again.

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