This question was answered on Wed 12, Feb 2014 04:15pm by Dr.Kokil Mathur

pregnancy

    
Asked by sksmaw (Female; 36; UNITED STATES; lat pregnancy HELLP SYNDROME had my daughter at 24 weeks ) on Tue 11, Feb 2014 06:00pm
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2 weeks ago I had an ultrasound which showed I had placenta previa that same day I took my second testing for AFP today it came back 1/63 down syndrome and 1/10 spinabifida. My last child who I had at 24 weeks due to help back in 2009 also came back with high risk for down syndrome but my ultrasounds showed fine and when she was born she did not have down syndrome I did have a small placenta abruption with her during my whole pregnancy could these be related to these test showing high risk.? Also with my last pregnancy I had a false positive for sypohillis and this pregnancy I had the same thing any connection and why the false positive for syhlliss all the time?

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Answer by Dr.Kokil Mathur  on Wed 12, Feb 2014 04:15pm:

Hi! I can appreciate your concerns as this is the second time you are having Down Syndrome and syphilis scare. The bacteria which cause syphilis, Treponema pallidum, are normally present in the mouth and oral swabs are often showing false positive results in pregnancy. In your case, this could be the reason for false positives. So, specific antibody tests are done to rule out syphilis. AFP levels alone are not indicative of Down Syndrome. You will need other tests (blood estrogen and HCG levels) and ultrasound to confirm or refute the suspicion. In Downs syndrome, AFP and estrogen are low and HCG is very high. Amniocentesis is done in highly suspicious cases. If you have placenta previa, then you may need regular ultrasounds to manage the progress of the baby. So, the radiologist will also closely monitor for signs of Downs Syndrome. Also, as pregnancy approached full term, placenta is often pulled up and the placenta previa disappears. Please feel free to ask anything else you may want to know. Take care!

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Comment by Dr Arti Sharma on Thu 13, Feb 2014 05:12am:
Hello and thank you for posting this query. Placenta praevia usually migrate upward with the enlarging uterus and at term are not low-lying. If a woman had placenta praevia in a past pregnancy she is at slightly increased risk of this occurring in a subsequent pregnancy.Smoking, more number of Csections are all risk factors for occurrence of placenta praevia.Normally, low levels of AFP can be found in the blood of a pregnant woman. No AFP (or only a very low level) is generally found in the blood of healthy, nonpregnant women. If a screening test is positive there are chances that your baby is more likely to have that birth defect. It needs to be confirmed by a diagnostic test. Few conditions like malaria, pneumonia, pregnancy, SLE and tuberculosis can all produce false positive tests for syphilis .Follow-up testing is necessary for confirming the diagnosis. This is merely an advice. You should clarify your doubts and concerns with a qualified gynecologist. Keep me posted with more queries. Best luck and kind regards!

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