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This question was answered on Sun 13, Dec 2009 10:16pm by Dr Bhupinder K, MD
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Please Help!!! Drug Overdose...






    
Asked by falnangl4u (Female; 64; Pain / Depression / Suicide Overdose; Relevant drugs:29 Lorcet, 100 Tramadol, 100 Lunesta, 55 Clonazepen ) on Sun 13, Dec 2009 11:22am :

My mother took these pills from the note she left. It took 13 days to find her body in a parked car. She did not appear to have been dead long and I was told from 1 to 2 days to several days because of cooler weather. Could you PLEASE tell me what the probable results would have been? I talked to her for over 8 hrs. on the cell phone before she stopped answering, but she had no phone charger. I have nightmares... How long would it have been before she went into coma? Please be honest, as no truth could be as horrible as imagination. There was no vomit. Please help me...

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Answer by Dr Bhupinder K, MD (doctor) on Sun 13, Dec 2009 10:16pm:

Hello, Welcome to the AMD forum of doctors and we are glad to help you out. First of all I offer my condolence for the sudden demise of your mother and I am really sorry for the loss that you have faced. I can understand that this loss in unbearable and unrepairable but I am sure that with your will power you can overcome all grief and sorrow. My best wishes are with you. As regards to these drugs that you have mentioned, one point that I would like to mention is that antiepileptic drugs like Clonazepam increase the risk of suicidal thoughts or behavior and may also cause depression. So if your mother was taking this drug before hand, then it could have been acted as a catalyst for her suicidal thoughts. Now regarding the cause of death, all these drugs could have played a role as overdose of all these can cause fatality. Two drugs out of these i.e. Lunesta and Clonazepam are both central nervous system depressants and cause somnolence( increased sleepiness), confusion, coma and diminished reflexes in overdose. Moreover taking both these drugs in overdose will ultimately lead to coma and hence death. Adding more fuel to the fire is the most lethal combination of all these i.e. Lorcet ( hydrocodone and acetaminophen). Not only it causes extreme somnolence progressing to stupor or coma, but it also causes a serious fall in blood pressure (hypotension), bradycardia (decreased pulse rate) and respiratory depression( by effecting the respiratory centre of the brain). So during somnolence and coma, if the respiratory centre is depressed it will lead to death. Thus taking all these drugs together and in overdosage lead to one incident(somnolence) to another(coma) and ultimately mortality. I sincerely hope this answer gives you the relevant information of the various causes that could have led to your mother’s demise. Please do keep us posted in case you have any additional queries. May God grant peace to the departed soul and strength to you to come over this moment of crisis. Warm regards. I am forwarding you two links which can give you more detailed information about these drugs. The sites are: http://www.rxlist.com/vicodin-drug.htm http://www.rxlist.com/klonopin-drug.htm
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Follow up:

Clarification by falnangl4u on Mon 14, Dec 2009 03:43am:
Thank you for your answer, it is very informative but still the thing which bothers me the most is the time frame of things. This started around 1:00 a.m. the last phone call at 9:00 p.m. She was very sleepy and hard to talk to at that time, but it was 13 days before she could be found. My problems are in that which I so terribly need answers to. Do you thing she would have fallen into a coma the first nite and her body took several days to die or would she have suffered just waiting to die for days??? As I stated there was no vomit nor had she had a bowel movement when found if that means anything. Also if you wouldn't mind adding to this, how would a tox report be affected with the 13 days wait? Would her body have continued to filter the drugs throughout the time? I requested an autopsy mainly for a time/date of death even willing to pay for it but was refused. Thank you so much for your help, I have gotten more for you at this point from anyone throughout this.
Request for Clarification by Dr Bhupinder K, MD on Mon 14, Dec 2009 07:59am:
Hi, Thanks a lot for clarification and giving further details of the same. Honestly speaking, it’s extremely difficult to assess the time of death without an autopsy but some idea can be had from the temperature of the body as it tends to decrease after death (by measuring the core temperature) but this is possible only during the first 24 hours. Secondly, it can be done by seeing the rigor mortis (which is due to the stiffness of the muscles) but this is also possible only during the first 36 hrs as the muscles tend to relax after that. There’s a possibility of your mother going into coma and the person can remain alive for many days as the metabolism of the body significantly slows down and thus the requirement of calories and energy also decreases. The chances of a person remaining in coma for a longer time when the outside temperature is towards the lower side is also high as that also tends to lower the body metabolic rate. Overall, it’s extremely difficult to predict the exact time of death but if significant decomposition of the body had not taken place, there’s a high chance of your mother remaining in coma for a long time before dying. I sincerely hope that helps. Take care.
Request for Clarification by Dr. A. Srivastava on Mon 14, Dec 2009 08:25am:
Hi, Dr. Bhupinder has already explained all the causes of death in very accurate manner. However, I would like to only add that without the autopsy reports no doctor can be precise about timing/cause of death. In autopsy, doctors usually take samples of viscera (stomach content, liver part etc.), urine sample to reach at probable cause of death. If she would have been entered in comatose state due to drug overdose ( as we can just suspect it) the body becomes unable/ slow in filter-up drugs in body and only life saving vital functions takes place thereby aggravating the coma state and can lead to eventual death. Other factors such as body temperature changes, decomposition (late in cold) and rigor mortis (stiffening of muscles) will be important determinants in finding out the probable time of death. Therefore, only investigators can be more precise about the cause/timing of any suspicious deaths. Hope this helps.
Clarification by falnangl4u on Mon 14, Dec 2009 08:47am:
I thank you so very very much, but am still left with the question that with the pills taken in your opinion do you think that she would have went into the coma on that very night of taking them? I apologize for being such a pain, of the original question I have much more on the symptoms it would have caused than I expected to recieve. I understand that a time or date is impossible, but I still am left with the wonder of would that combination of pills have put her into a coma probably that night sometime? Again I thank you more than you could possibly know for your time!
Request for Clarification by Dr Bhupinder K, MD on Mon 14, Dec 2009 10:36am:
Hi, I can understand the turmoil of emotions and questions that are going in your mind at the moment. There is a high chance of your mother slipping into coma the same days or the next day because of the number of pills of each drug that she had consumed. Take care and God bless.
Clarification by falnangl4u on Mon 14, Dec 2009 07:08pm:
THANK YOU AND GOD BLESS!!!


Comments:

Response by Dr Bhupinder K, MD on Mon 14, Dec 2009 07:58am:
Hi, Thanks a lot for clarification and giving further details of the same. Honestly speaking, it’s extremely difficult to assess the time of death without an autopsy but some idea can be had from the temperature of the body as it tends to decrease after death (by measuring the core temperature) but this is possible only during the first 24 hours. Secondly, it can be done by seeing the rigor mortis (which is due to the stiffness of the muscles) but this is also possible only during the first 36 hrs as the muscles tend to relax after that. There’s a possibility of your mother going into coma and the person can remain alive for many days as the metabolism of the body significantly slows down and thus the requirement of calories and energy also decreases. The chances of a person remaining in coma for a longer time when the outside temperature is towards the lower side is also high as that also tends to lower the body metabolic rate. Overall, it’s extremely difficult to predict the exact time of death but if significant decomposition of the body had not taken place, there’s a high chance of your mother remaining in coma for a long time before dying. I sincerely hope that helps. Take care.

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