Toxicity due to chemotherapy - What does Grade 1 constipation and Grade 1 PPE mean?

	Asked by Unregistered on Wed 12, Mar 2008 07:40am
	I have undergone 18 weeks chemo for recurrent disease of cancer of the oesophagus. Toxicity from my chemotherapy includes grade 1 constipation and grade 1 PPE. What does PPE mean?
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	Answer by Dr Bobby V, MD (doctor) on Wed 12, Mar 2008 08:22am: Hi, PPE refers to "Palmer-Planter Erythrodysesthesia", more commonly known as the "Hand-Foot Syndrome". It is an adverse effect of chemotherapy drugs. 5-Fluorouracil (5FU), capecitabine, doxorubicin, docetaxel, idarubicin, and cytarabine are the most frequently involved agents. This syndrome consists of of redness, tenderness, tingling, numbness, dry rash, and desquamation over the palms and soles. You can get a detailed description of this syndrome at the following site. http://patient.cancerconsultants.com/SideEffects.aspx?DocumentId=23169
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