Lump in side that is hard and hurts, waist height right side.

	Asked by Unregistered on Sat 29, Mar 2008 10:29am :
	I have a dull ache on my right side about waist hieght. There seems to be a hard lump there. My urine has made me ache a little inside like an infection but i do not get a burning sensation just a dull pain that seems to be like from my bladder. Not sure if these are related or not please help. Do not think it is cancer however my Dad has Muis Torres syndrome and says i need to get checked out which if i had the genes could cause cancerous lumps throught my body. i am 42 and have a lump in my side that seems solid and hurts if i press on it.
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	Answer by Dr Bobby V, MD (doctor) on Sun 30, Mar 2008 10:48am: Hi, If your dad has Muir-Torre Syndrome (MTS), then you should see a doctor for a physical examination. MTS, as I am sure you know, is a condition where a skin (sebacious) malignancy and a visceral (eg gastrointestinal or urinary) malignancy are both seen in a patient with some genetic defects. It is inherited in a manner called "autosomal dominant" in genetic parlance. It also has "high penetrance" ie it manifests symptoms in a majority of persons in whom this genetic defect is present. You also have some urinary symptoms. This by itself may not mean anything serious. But given the background of MTS in the family, it should not be ignored. I think that the prudent course would be to get yourself evaluated by a physician. Explain to him your family history. He may like to order some specialized genetic tests like MSI (microsatellite instability) and gene sequencing for hMLH1 and hMSH2. Also, not every child of a MTS parent gets the disease. Good luck!
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